Welcome To My Blog

Thanks for Visiting my Blog :)
I wrote my minds in here, I hope my articles will be useful for you.
If you don't mind, please, be my follower so that we can share our minds, thanks.

mylife-diechemie.blogspot.com
My Email: dertraum0127@gmail.com

Thank you for all participants supporting this blog. Especially the download link's sources and bibliographies.

I'm not an expert teacher or lecturer of chemistry. I was only a student from SMA NEGERI 15 SURABAYA who had been one of the Bronze Medalist Participants of Olimpiade Sains Nasional X (2011) of Chemistry In Manado, North Sulawesi, 11 - 16 September 2011 and graduated in 2012. Now, I'm studying at Universitas Airlangga in Surabaya, Indonesia. I do love chemistry and I would like to help them who had difficulties in studying chemistry. That's why, please understand me if you found some misconcepts in my entries. Suggestions are always necessary in order to develop this blog. And I'm sorry because my English isn't so well.

All posts are originally created by me. I never stole from any sites or somebody's blog. Although sometimes I took pictures or data from other sites, I always wrote the source of that pictures or data.


Protected by Copyscape Unique Content Checker

Thursday, January 05, 2012

Mefenamic Acid

Mefenamic acid is a non-stereoidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid is marketed in the USA as Ponstel. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. There is also evidence that supports the use of mefenamic acid for perimenstrual migraine headache prophylaxis, with treatment starting 2 days prior to the onset of flow or 1 day prior to the expected onset of the headache and continuing for the duration of menstruation.

Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.

Overdose can lead to a range of symptoms including convulsions, nausea, vomiting, vomiting blood, shallow breathing, coma. Onset of symptoms is usually between 30 minutes and 4 hours, but signs of renal failure may appear several days after an overdose. Seek medical attention immediately in the case of overdose. The lethal dose can be as low as 2.5g.

Synthesis
I will use my version because I don't have complete data yet (I created this synthesis before read wikipedia).



What makes me not sure is the last step. We know that benzene is an quite-inert compound so does Chlorobenzene so that I don't know the exact condition to make the 2,3-methyl aniline can be reacted with the chlor from 2-chlorobenzoic acid.

Further Reading . . .
Wikipedia

No comments:

Post a Comment