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I'm not an expert teacher or lecturer of chemistry. I was only a student from SMA NEGERI 15 SURABAYA who had been one of the Bronze Medalist Participants of Olimpiade Sains Nasional X (2011) of Chemistry In Manado, North Sulawesi, 11 - 16 September 2011 and graduated in 2012. Now, I'm studying at Universitas Airlangga in Surabaya, Indonesia. I do love chemistry and I would like to help them who had difficulties in studying chemistry. That's why, please understand me if you found some misconcepts in my entries. Suggestions are always necessary in order to develop this blog. And I'm sorry because my English isn't so well.

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Thursday, March 29, 2012

The Kinetic of Enzymes: Briggs - Haldane Methode

Do you know the Michaelis - Menten Equation of the rate of enzymatic reaction as follows?



Where [S] is the concentration of the substrate, V is the rate of reaction, and KM is the Michaelis - Menten constant. Now my question is: Where does this equation come from?

Leonor Michaelis and Maud Menten use limits and another calculus to create this equation. Because I hate mathematics, I will write another method to prove the truth of this equation by using Briggs - Haldane Kinetics.

The concept of this method is the steady - state approximation. First, we have to write an enzymatic equation first:



Now, we now that the law or rate of reaction for this reaction is: V = k2 [ES]. We have to determine the [ES] by steady - state approximation.









From this methode, we also know what is the equation to determine VMax and KM.


Thank You.

Source:
Document of Pelatnas 2 IChO 2012


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